Hepatotoxicity Of The Ethanolic Extracts Of Enantia Chlorantha Root On Wistar Albino Rats

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Abstract

The root of Enantia chlorontha was assayed for its hepatotoxicity effect. Extacts from the root were made using 95% ethanol. The root extracts were administered orally to 15 wistar albino rats and varying doses. 5 rats were kept as control group. The effect of the extracts was determined by assaying for the levels of serum-liver enzymes acting as biochemical makers. Liver enzymes assayed included Aspartate aminotransferase (AST), Alanin aminiotransferase (ALT) and alkaline phophatase (ALP). Comparison of the enzyme levels of the control group with these of the group administered with the rot extract revealed a significant elevation of liver enzyme levels

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Project Info Table of Content Reviews

Type:Project Material

Format:PDF/DOC

Title Page i
Certification ii
Dedication iii
Acknowledgement iv
Table Of Content i
Abstract ix

Chapter One
1.0 Introduction 1
1.1 Background Of The Study 1
1.2 Aims And Objectives 6
1.3 Statement Of Problem 7
1.4 Limitation Of Study 7
1.5 Significance Of The Study 8

Chapter Two
2.0 Literature Review 9
2.1 General Description Of Enantia Chlorontha 10
2.2 Ecological Distribution Of Enantia Chlorantha 10
2.3 Management And Propagation Practices 11
2.4 Functional Uses 12
2.5 Toxicity 13
2.6 Hepatotoxicity 17
2.7 Liver 20
2.7.1 Liver Enzyme 22
2.7.2 Some Pattern Of Liver Injury 23
2.7.3 Treatment/Prognosis Of Liver Damage 28
2.8 The Albino Rats 29
2.9 Phytochemical Compounds 31

Chapter Three
3.0 Materials And Methods 32
3.1 Collection, Identification And Processing Of Plant Material 32
3.1.1 Extraction Of Plant Material 33
3.1.2 Determination Of The Weight Of Dried Extract 34
3.2 Phytochemcial Analysis 35
3.3 Experimental Animal 43
3.4 Determination Of Dosage Of The Plant Extract For Animal Feeding 43
3.5 Grouping Of Animal And Administration Of Plant Extract 44
3.6 Feeding Method 45
3.7 Procedures For Blood Sample Collection 46
3.7.1 Alanine Aminotransferase Test (Alt) Method For Alt Test 47
3.7.2 Aspartate Animotransferase: (Ast) Method For Ast Test 48
3.7.3 Alkaline Phousphatase: (Alp) Method For Alp Test 49

Chapter Four
4.0 Results 50
4.1 Result Of The Photochemical Analysis Of The Ethanolic Extract Of Enantia Chlorontha 50
4.2 Hepatotoxicity Assay 55

Chapter Five
5.1 Discussion 58
5.2 Conclusion 60
5.3 Recommendation 60
References 61

Effects Of Vitamin Supplementation On Lead Toxicity In Wistar Albino Rats.

This study was carried out to evaluate the effect of vitamin supplementation on lead toxicity in wistar albino rats. A total of forty male Wistar rats (six-weeks-old) was divided into 4 groups: control group; lead-acetate (PbAc)-treated group (20 mg PbAc/kg bwt); PbAc+ VC-treated group (20 mg PbAc/kg bwt plus 20 mg VC/kg bwt); and VC-tre […]

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APA

Hepatotoxicity Of The Ethanolic Extracts Of Enantia Chlorantha Root On Wistar Albino Rats. (n.d.). UniProjects. https://uniprojects.net/project-materials/hepatotoxicity-of-the-ethanolic-extracts-of-enantia-chlorantha-root-on-wistar-albino-rats/

MLA

“Hepatotoxicity Of The Ethanolic Extracts Of Enantia Chlorantha Root On Wistar Albino Rats.” UniProjects, https://uniprojects.net/project-materials/hepatotoxicity-of-the-ethanolic-extracts-of-enantia-chlorantha-root-on-wistar-albino-rats/. Accessed 21 September 2024.

Chicago

“Hepatotoxicity Of The Ethanolic Extracts Of Enantia Chlorantha Root On Wistar Albino Rats.” UniProjects, Accessed September 21, 2024. https://uniprojects.net/project-materials/hepatotoxicity-of-the-ethanolic-extracts-of-enantia-chlorantha-root-on-wistar-albino-rats/

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Biochemistry (206), Chemistry Education (339), Chemistry (240)

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Hepatotoxicity, Ethanolic Extracts, Enantia Chlorantha Root, Wistar Albino Rats